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Target intelligence / Profile preview
MicroRNA 328 (miR-328)
- Target
- miR-328
- Molecular classification
- Non-coding RNA, MicroRNA
01
Overview
MicroRNA 328 (miR-328) is a small, non-coding RNA molecule that regulates gene expression post-transcriptionally. It functions both as a canonical microRNA, binding to target mRNAs and causing translational repression or degradation, and as an RNA decoy, sequestering proteins like hnRNP E2. It plays a role in cancer biology, cardiovascular function, and other physiological processes. Dysregulation of miR-328 is implicated in various diseases, including cancer, leukemia, and atrial fibrillation.
- Other names
- MIR328
02
Mechanism of action
Binds to target mRNAs (e.g., ABCG2, ITGA5, CACNA1C/CACNB1, PIM kinases) leading to translational repression or mRNA degradation; Functions as RNA decoy for regulatory proteins like hnRNP E2.
03
Biological functions
Gene expression regulationTumor suppressionRegulation of angiogenesisRegulation of electrical remodelingRNA-protein decoyCell differentiationMorphogenesis
04
Disease associations
CancerLeukemiaCardiovascular diseaseKidney injuryHeart valve pathologyTraumatic brain injury
05
Safety considerations
Dysregulation implicated in multiple diseasesTherapeutic manipulation may have off-target effects
06
Interacting drugs
Docetaxel (sensitization)
1 more in the full profile.
07
Biomarkers
miR-328 expression levels in cancer tissuesmiR-328 expression levels in cerebrospinal fluid/serum for TBI diagnosis
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