MicroRNA 329-1 (MIR329-1)

MicroRNA 329-1 (MIR329-1) is a small, non-coding RNA molecule belonging to the microRNA class, encoded in the human genome[1]. Like other microRNAs, MIR329-1 regulates gene expression at the post-transcriptional level, primarily by binding to complementary sequences in the 3′ untranslated region (3′UTR) of target messenger RNAs (mRNAs), leading to translational inhibition or mRNA degradation[1]. MIR329-1 plays a critical role in controlling cell proliferation, cell cycle progression, and apoptosis by targeting specific genes, including transcription factors and signaling mediators such as p130Cas and TCF7L1[2][3]. It acts as a tumor suppressor in several cancers, including breast and lung cancer: its expression is frequently downregulated by mechanisms such as DNA methylation, with lower MIR329-1 levels correlating with tumor growth, increased cell migration, and poor prognosis[2][3]. Restoration or mimicry of MIR329-1 function is under investigation as a cancer therapeutic strategy. MIR329-1 is not a classical receptor, enzyme, or transporter but is considered a non-coding RNA regulatory target with therapeutic relevance[1][2][3].

Other names

hsa-mir-329-1MIRN329-1mir-329-1MIR329-1

Not applicable; MIR329-1 is itself a regulatory RNA, not a typical druggable protein target. In diseases where upregulation of MIR329-1 is beneficial (e.g., as a tumor suppressor), approaches may include synthetic miRNA mimics, gene therapy, or epigenetic modifiers (such as demethylating agents) that restore MIR329-1 expression[2][3].