MicroRNA 345 (miR-345)

MicroRNA 345 (miR-345) is a small, non-coding RNA molecule encoded on human chromosome 14q32.2 that functions mainly as a regulator of gene expression post-transcriptionally, by binding target mRNA and inhibiting its translation or promoting its degradation. miR-345 is implicated in the regulation of genes involved in apoptosis, cell proliferation, cell cycle, EMT, and chemoresistance, and is widely studied for its tumor suppressor roles in pancreatic, colorectal, prostate, liver, and breast cancers. Its expression is often downregulated in malignancies, correlating with more aggressive disease and chemoresistance. Restoration of miR-345 can induce apoptosis in cancer cells, making it a promising target for therapeutic intervention and a potential biomarker for prognosis and therapeutic response in oncology

Other names

hsa-miR-345MIRN345MIR345mir-345hsa-mir-345

Regulation of target gene expression via base pairing with mRNA, leading to translation repression or mRNA degradation Direct downregulation of key survival and anti-apoptotic proteins (e.g., BCL2, BAG3, ABCC1/MRP1, YAP1, SHH, MUC4) Modulation of signaling pathways such as PI3K/AKT, mTOR, and YAP/TAZ Restoration or inhibition of miR-345 can induce or block apoptosis in cancer cells