MicroRNA 34b (miR-34b)

MicroRNA 34b (miR-34b) is a short, non-coding RNA molecule that regulates gene expression post-transcriptionally by binding predominantly to the 3’ untranslated regions of target messenger RNAs, inhibiting their translation or promoting degradation[4][1]. As a member of the miR-34 family, miR-34b has a well-established tumor suppressor role: it is typically downregulated in cancers and mediates suppression of oncogenes such as MYC and MET, inducing cell cycle arrest, promoting apoptosis, and inhibiting proliferation, invasion, and migration[3][2][7]. Its function is tightly linked to the p53 tumor suppressor pathway[1]. Beyond cancer, miR-34b participates in regulation of development, immune responses, spermatogenesis, and cilia function[1][6]. Its expression and methylation status are valuable biomarkers for disease state and therapeutic response, especially in cancer. It is being explored as a therapeutic target via miRNA mimics, though challenges remain for effective and safe delivery in clinical settings[1][7].

Other names

hsa-miR-34bMIR34BMIRN34BmiRNA34Bmir-34bhsa-mir-34bMIR34B-5pmiR-34b-5p

Gene silencing by binding to 3’ untranslated regions of target mRNAs, leading to mRNA degradation or translation inhibition[1][4] Suppression of oncogenic targets (e.g., MYC, MET) by post-transcriptional repression[2][3][7] Tumor suppressor function via induction of cell cycle arrest and apoptosis[1][3][7]