MicroRNA-361-3p (miR-361-3p)

MicroRNA-361-3p (miR-361-3p) is a small, non-coding RNA molecule that plays a critical role in the post-transcriptional regulation of gene expression [1]. It functions by binding to complementary sequences within the 3' untranslated regions (UTRs) of specific target mRNAs, resulting in gene silencing through translational inhibition or transcript degradation [2]. In many pathological contexts, particularly oncology, miR-361-3p frequently acts as a tumor suppressor, inhibiting processes such as cell proliferation, epithelial-mesenchymal transition (EMT), and metastasis by targeting oncogenic pathways like Wnt/beta-catenin and PI3K/Akt [3, 4]. Conversely, its downregulation is often associated with poor prognosis and advanced disease stages in various cancers, including lung, breast, and colorectal carcinomas [5]. Beyond cancer, miR-361-3p is involved in cardiovascular health and inflammatory responses [6]. While currently primarily a research focus, therapeutic strategies involving miR-361-3p mimics or inhibitors are being explored to restore normal regulatory networks in diseased tissues [7].

Other names

hsa-miR-361-3pMIR361MicroRNA 361

Binds to the 3' untranslated region (UTR) of target messenger RNAs (mRNAs) to induce translational repression or mRNA degradation [1, 2].