MicroRNA 3614 (miR-3614)

MicroRNA 3614 (miR-3614) is a non-coding RNA molecule expressed in human cells that functions primarily in the post-transcriptional regulation of gene expression through RNA silencing mechanisms. miR-3614 has been shown to play a role in regulating inflammatory responses by targeting tumor necrosis factor receptor-associated factor 6 (TRAF6), which suppresses activation of the MAPK and NF-κB pathways in macrophages, particularly in the context of coronary artery disease[1][5]. It also acts as a tumor suppressor in various cancers; for example, miR-3614-5p downregulates the anti-apoptotic protein Mcl-1, thereby promoting apoptosis in prostate cancer cells[2]. Additionally, miR-3614-5p exhibits antiviral activity and modulates expression of proteins like ADAR1, which are implicated in host responses to viral infection and the replication cycle of flaviviruses such as dengue virus[4]. The therapeutic potential of miR-3614 centers on its ability to regulate inflammation, cell proliferation, and apoptosis, but no drugs directly targeting miR-3614 are in routine clinical use. Altered levels of miR-3614 may serve as biomarkers for monitoring inflammation or cancer status, although its clinical application for patient selection is still experimental.

Other names

hsa-miR-3614miR-3614miR-3614-5pmiR-3614-3p

For theoretical/experimental drugs: Antisense oligonucleotides or miRNA mimics may target miR-3614 to modulate its activity, but clinical application remains investigative[2][4].