MicroRNA 3619 (miR-3619)

MicroRNA 3619 (miR-3619) is a small (~22 nucleotide) non-coding RNA molecule belonging to the microRNA family, and is involved in the negative regulation of mRNA via RNA interference mechanisms. miR-3619 is endogenously expressed in normal tissues, but commonly downregulated in several cancers including breast and bladder cancer. Functionally, miR-3619 acts as a tumor suppressor: its overexpression inhibits cell proliferation, migration, invasion, and epithelial–mesenchymal transition (EMT), and induces cell cycle arrest and apoptosis by targeting mRNAs including those coding for β-catenin, CDK2, and by activating the p21 gene promoter. In cancer biology, miR-3619 loss facilitates tumor progression through the de-repression of oncogenes and suppression of anti-proliferative factors. miR-3619 thus represents a promising biomarker and a putative therapeutic target in oncology, with clinical implications for disease prognosis, monitoring, and targeted therapy development.

Other names

MIR3619miR-3619-5phsa-mir-3619

Not directly applicable. As a microRNA, therapeutic strategies involve either restoration (using mimics) in cases where miR-3619 acts as a tumor suppressor, or inhibition (using antagomiRs) if antagonizing pathological activity. The main therapeutic mechanism is gene expression modulation via RNA silencing or, as recent reports suggest, RNA activation (RNAa) of specific genes such as p21