MicroRNA 3622a (miR-3622a)

MicroRNA 3622a (miR-3622a) is a short, non-coding RNA molecule belonging to the microRNA class of regulatory RNAs. It is transcribed from the human genome and processed by the Drosha and Dicer RNases to a mature form that binds to target mRNAs, usually through imperfect complementarity, to mediate mRNA degradation or translational repression. miR-3622a is found at the 8p21.1 locus, a region often deleted in multiple cancer types. It has been shown to act as a tumor suppressor in colorectal cancer by suppressing cell proliferation, migration, and invasion, and inducing cell cycle arrest and apoptosis, particularly by targeting SALL4 and modulating Wnt/β-catenin and epithelial-mesenchymal transition (EMT) pathways. Its role in prostate cancer appears more complex, with evidence for both tumor-suppressive and, in some contexts, tumor-promoting effects, likely due to interplay with related microRNAs at the same locus. If you intend this to refer to a druggable receptor, enzyme, or transporter, note that microRNAs like miR-3622a are not classified as such and do not serve as conventional therapeutic "targets" in the classic sense.

Other names

hsa-mir-3622amir-3622aMIR3622AmiR-3622a-3p

Not applicable for conventional drugs, but miR-3622a exerts its biological effects through base pairing with target mRNAs to promote their degradation or translational inhibition (typical of all microRNAs)