MicroRNA 363-3p (miR-363-3p)

MicroRNA 363-3p (miR-363-3p) is a small non-coding RNA molecule that plays a critical role in the post-transcriptional regulation of gene expression by binding to the 3' untranslated regions (UTRs) of target mRNAs (miRBase, 2024). It is part of the miR-106a-363 cluster located on the X chromosome and is involved in various biological processes including cell proliferation, apoptosis, and the epithelial-mesenchymal transition (PubMed, PMID: 30106424). In oncology, miR-363-3p exhibits dual roles; it acts as a tumor suppressor in colorectal and head and neck cancers by targeting oncogenes like NOTCH1, while it may promote progression in other contexts such as certain neuroblastomas (PubMed, PMID: 28415635, PMID: 25670303). Beyond cancer, it has been linked to cardiovascular development and the regulation of hematopoietic stem cells. Therapeutic strategies targeting miR-363-3p involve the use of miRNA mimics to restore its function in cases of downregulation or antagomirs to inhibit its activity when overexpressed, though these remain largely in the preclinical research stages (Nature Reviews Drug Discovery, 2020). Its expression levels in tissue and biofluids are also being explored as potential biomarkers for disease diagnosis and prognosis.

Other names

hsa-miR-363-3pMIR363miR-363MicroRNA 363

Post-transcriptional gene silencing via mRNA degradation or translational repression through seed sequence binding to the 3' untranslated region (UTR) of target messenger RNAs (PubMed, PMID: 30106424).