microRNA 3658 (miR-3658)

microRNA 3658 (miR-3658, hsa-miR-3658, MIR3658) is a member of the microRNA (miRNA) family, which consists of short (20–24 nucleotide) non-coding RNAs involved in the post-transcriptional regulation of gene expression in multicellular organisms by modulating both the stability and translation of target mRNAs[2][3][4][5]. miR-3658 is transcribed as part of a primary miRNA (pri-miRNA), processed in a multistep pathway involving Drosha and Dicer ribonucleases, and incorporated into the RNA-induced silencing complex (RISC). Within RISC, miR-3658 recognizes and binds its target mRNAs, typically resulting in translational inhibition or mRNA destabilization[2][3][5]. miR-3658 has been implicated in multiple cancers: it is upregulated in bladder cancer—correlating with aggressive clinicopathological features, such as lymph node invasion, metastasis, and tumor recurrence, and may serve as a prognostic biomarker in this context. Conversely, in colorectal cancer, miR-3658 is downregulated; restoration of its expression suppresses the pluripotency marker OCT4, leading to growth inhibition and reduced migration, supporting a tumor-suppressive role and highlighting its potential as a diagnostic and prognostic biomarker[2]. Overall, miR-3658 represents a functionally important, non-coding regulatory RNA with context-dependent roles in human disease, particularly cancer.

Other names

hsa-mir-3658MIR3658hsa-miR-3658