MicroRNA 365a (miR-365a)

MicroRNA 365a (miR-365a) is a small non-coding RNA molecule involved in the post-transcriptional regulation of gene expression by targeting messenger RNAs for translational repression or degradation. It has key biological roles in promoting chondrocyte proliferation and differentiation by targeting HDAC4, is mechanoresponsive, and is implicated in epigenetic regulation of chromatin. miR-365a additionally regulates cardiac ion channel expression, thereby affecting cardiac electrophysiology, and altered miR-365a levels are associated with various cancers and cardiac arrhythmias. It is currently under investigation as a potential therapeutic target, particularly using inhibitory oligonucleotides in preclinical cancer models[1][2][3][4].

Other names

hsa-mir-365-1MIR365-1MIRN365-1hsa-mir-365amir-365amicroRNA 365-1MIR365A

post-transcriptional gene silencing (binding 3'-UTR of target mRNAs), inhibition of histone deacetylase 4 (HDAC4), downregulation of repolarizing ion channels