MicroRNA 365b (miR-365b)

MicroRNA 365b (miR-365b) is a small, non-coding RNA molecule belonging to the microRNA (miRNA) family, functioning primarily in the post-transcriptional regulation of gene expression by influencing mRNA stability and translation[3][4]. Like other miRNAs, it is transcribed as a precursor transcript that is processed into a mature form and incorporated into the RNA-induced silencing complex (RISC), where it binds target mRNAs via sequence complementarity causing translation inhibition or degradation[3]. miR-365b has been implicated in the regulation of cell proliferation, cell cycle arrest, and apoptosis in cancer contexts[1][5]. Specifically, it acts as a tumor suppressor in non-small cell lung cancer cells by targeting PPP5C, leading to reduced proliferation and increased apoptosis[1]. Moreover, its expression patterns serve as potential biomarkers in cancer classification studies, such as in brain metastases and multiple myeloma[2][7][5]. No direct interacting drugs or established mechanisms of action for drug targeting are reported to date.

Other names

hsa-mir-365-2MIR365-2MIRN365-2hsa-mir-365bmir-365bmicroRNA 365-2MIR365B