microRNA 367 (miR-367)

microRNA 367 (miR-367) is a small, non-coding RNA molecule that belongs to the miR-302/367 cluster located intronically in the La-related protein 7 (LARP7) gene. It functions primarily as a regulator of gene expression at the post-transcriptional level by binding to specific sequences in the 3′ untranslated regions (3′UTRs) of target messenger RNAs, resulting in inhibition of translation or mRNA degradation. miR-367 plays crucial roles in cell proliferation, pluripotency maintenance, differentiation, cell cycle regulation, and reprogramming. It is highly expressed in embryonic stem cells and induced pluripotent stem cells but is also implicated in cancer biology, acting as both a tumor suppressor and, in some contexts, an oncogene. miR-367 has been experimentally validated to regulate genes such as PIK3R3 and RYR3, among others, and is involved in major signaling pathways such as PI3K–AKT, TGF-β/Nodal, and BMP. Its expression and function are tightly regulated, and genetic variants affecting miR-367 binding sites can influence disease susceptibility, especially cancer.

Other names

hsa-mir-367MIRN367MIR367mir-367

Inhibition of mRNA translation or promotion of mRNA degradation by direct binding to the 3′ UTR of target genes. Modulation of cellular signaling pathways, e.g., PI3K–AKT, BMP, TGF-β/Nodal/Smad, through downregulation of key pathway components.