MicroRNA 3681 (miR-3681)

MicroRNA 3681 (miR-3681; also known as hsa-miR-3681 or MIR3681) is a small non-coding RNA belonging to the microRNA family, typically acting in the range of 19–24 nucleotides[1][2][5]. miR-3681 is derived from a long terminal repeat (LTR) element on the p arm of human chromosome 2[1][2]. Its primary role is the post-transcriptional regulation of gene expression by binding to complementary sequences in the 3′ untranslated region (UTR) of target messenger RNAs (mRNAs), resulting in the inhibition of gene expression[1][2][3][5]. For miR-3681-5p, the only experimentally characterized target is SHISA7, a regulator of synaptic potentiation; miR-3681-5p can act as a gene expression enhancer under certain conditions, especially in the context of variable number tandem repeats (VNTRs) within SHISA7's 3′ UTR[1]. Studies suggest that miR-3681 may play roles in neurological function (via SHISA7 regulation), cancer biology (notably, altered expression in some cancers), and other disease processes, though these associations are not yet fully characterized or therapeutically validated[1][2][5]. There are currently no known drugs targeting miR-3681, and its direct use as a biomarker or therapeutic target is not established in clinical practice[5]. Its primary biological significance lies in its contribution to the regulatory complexity of the transcriptome through non-coding RNA-mediated mechanisms.

Other names

hsa-mir-3681hsa-miR-3681MIR3681miR-3681-5pmiR-3681-3p