MicroRNA 369-5p (miR-369-5p)

MicroRNA 369-5p (miR-369-5p) is a small non-coding RNA molecule that plays a critical role in the post-transcriptional regulation of gene expression. It is part of the large DLK1-DIO3 imprinted cluster on chromosome 14, which is frequently associated with developmental processes and various pathologies (Benetatos et al., Cellular and Molecular Life Sciences, 2013). While most microRNAs function primarily as repressors of translation, miR-369-5p is notable for its ability to switch from a repressor to an activator of translation under specific cellular conditions, such as during the G0 phase of the cell cycle, where it has been shown to upregulate TNF-alpha (Vasudevan et al., Science, 2007). In the context of oncology, miR-369-5p often functions as a tumor suppressor by targeting oncogenes involved in proliferation and epithelial-mesenchymal transition (EMT), such as ZEB1 and SOX2, though its role can be context-dependent (Journal of Cellular Biochemistry, 2018). It has also been implicated in inflammatory responses and neurodegenerative conditions like Alzheimer's disease, where its downregulation is often observed (Frontiers in Aging Neuroscience, 2021). Therapeutic strategies targeting miR-369-5p involve the use of synthetic mimics to restore its function in cancer or antagomirs to inhibit its activity in conditions where it may contribute to disease progression.

Other names

hsa-miR-369-5pMIR369MicroRNA 369miR-369

Binds to the 3' untranslated region (UTR) of target mRNAs to induce translational repression or mRNA degradation; uniquely, it can also mediate translational activation during cell cycle arrest (G0 phase) by recruiting the AGO2-FXR1 complex (Vasudevan et al., Science, 2007).