MicroRNA 371b (miR-371b)

MicroRNA 371b (miR-371b) is a member of the microRNA family, consisting of short (20-24 nucleotides), single-stranded non-coding RNA molecules that regulate gene expression post-transcriptionally, primarily by base pairing with target mRNA sequences to promote degradation or inhibit translation[5][6]. In cancer biology, miR-371b-5p has been identified as a tumor-suppressive miRNA in triple-negative breast cancer (TNBC), acting to reduce cell proliferation, migration, and invasion[1]. It directly targets CSDE1, a proto-oncogene involved in cell growth, differentiation, and apoptosis pathways, and regulates the CSDE1/RAC1 axis that drives tumor progression in TNBC[1]. Loss of miR-371b-5p is associated with poorer prognosis in TNBC and may serve as a prognostic biomarker for patient outcomes[1]. Overall, miR-371b functions as a regulatory RNA with emerging disease relevance, especially in oncology. If more specific information is needed (e.g., direct drug interactions, mechanisms of action for potential therapeutics), further literature review is warranted, as current data indicate miR-371b is primarily studied as a biomarker and regulatory molecule, not as a conventional therapeutic target.

Other names

hsa-mir-371bMIR371BmiR-371bmiR-371b-5p