microRNA-374a-3p (miR-374a-3p)

microRNA-374a-3p is a single-stranded, non-coding RNA molecule of approximately 22 nucleotides, produced from the precursor MIR374A gene. It is detected in various human tissues and fluids, including plasma and cerebrospinal fluid. By binding to the 3′ untranslated regions of specific messenger RNAs, miR-374a-3p controls gene expression post-transcriptionally, impacting cell differentiation, proliferation, and migration. Importantly, miR-374a-3p is dysregulated in several cancers, most notably breast cancer, where its overexpression promotes EMT and metastatic potential via activation of Wnt/β-catenin signaling. It also plays roles in other disease states such as neurodegeneration and ischemic injury[2][3][5][1]. If you need more specific details (such as its exact sequence, predicted targets, or clinical studies), the miRBase entry (accession MIMAT0004688) provides curated data about hsa-miR-374a-3p[3].

Other names

hsa-miR-374a-3pMIR374A-3pmiR-374a-3p

Drugs (e.g., antagomirs or mimic oligonucleotides) would modulate miR-374a-3p levels to alter downstream target gene expression—for example, by inhibiting EMT and Wnt/β-catenin pathway activation in cancer