MicroRNA 374b (miR-374b)

MicroRNA 374b (miR-374b) is a small non-coding RNA molecule (microRNA) that functions as a post-transcriptional regulator of gene expression through base pairing with complementary sequences in target messenger RNAs (mRNAs), leading to mRNA degradation or inhibition of translation[5][2]. It is differentially expressed in various cellular states and tissues, including neural and mesenchymal stem cells, and it plays critical roles in cell proliferation, differentiation, apoptosis, and tumor suppression[1][2][3][4][6]. In cancer, miR-374b generally acts as a tumor suppressor, inhibiting cell growth and promoting apoptosis—specifically demonstrated in non-small cell lung cancer, colon cancer, and other malignancies, by targeting genes such as FOXP1, Hes1, JAM-2, and others[1][4][6][7]. Levels of miR-374b have been proposed as a prognostic and predictive biomarker for several diseases, and its modulation may hold therapeutic promise, although no drugs currently directly target this microRNA in clinical use.

Other names

hsa-mir-374bMIRN374BMIR374Bmir-374b-5pmicroRNA-374b-5p

Gene silencing by binding to 3'-untranslated regions (3’-UTRs) of target mRNAs, leading to inhibition of translation or mRNA degradation. Known targets include Hes1, MRF4, JAM-2, FOXP1, LRH-1, RECK, ZEB2, PD-1