MicroRNA 376a-2 (miR-376a-2)

MicroRNA 376a-2 is a small, non-coding RNA molecule in the human miR-376 cluster (14q32 locus), functioning primarily in post-transcriptional gene silencing. It is implicated in regulation of cell proliferation, apoptosis, and tumor invasion through direct targeting of specific mRNAs such as FOXP2 and SP1, and has a regulatory role in cancers including lymphoma and glioblastoma multiforme[1][3]. miR-376a-2 is usually downregulated in tumor tissues, and its overexpression suppresses proliferation and promotes apoptosis. In HGPS, it helps modulate cell cycle progression through CDK2 downregulation[2]. These properties suggest miR-376a-2 is both a potential therapeutic target and a disease biomarker. No direct drugs against miR-376a-2 are clinically approved, but miRNA mimics or inhibitors are active research topics. Its systemic targeting or modulation could have broad and unpredictable effects due to the multitude of genes it regulates.

Other names

hsa-mir-376a-2MIR376A2MIR376A-2MIRN376A-2mir-376a-2

Gene silencing by binding to target mRNAs (e.g., downregulation of FOXP2, SP1, CDK2); Tumor suppression via cell-cycle and apoptosis modulation