microRNA 376b (MIR376B)

MicroRNA 376b (MIR376B) is a single-stranded, noncoding RNA of about 22 nucleotides that regulates gene expression post-transcriptionally by binding to complementary sequences in target mRNAs, resulting in their degradation or translational inhibition. It is a member of the microRNA family and participates in the regulation of key cellular processes such as angiogenesis, autophagy, and tumor cell behavior. MIR376B specifically targets genes including ATG4, BECN1 (autophagy pathway), CEBPB, GLS1 (glutamine metabolism), and RGS1 (in tumor biology). Its altered expression is associated with pathological states including cancer, choroidal neovascularization, and potentially other conditions where cell proliferation and metabolism are dysregulated. MIR376B is under active investigation as a therapeutic target and as a molecular biomarker in several diseases.

Other names

hsa-miR-376bMIRN376BmiR-376bhsa-mir-376bMIR376B

Drugs (or experimental molecules) modulating microRNA 376b generally act by either: Mimicking or inducing its expression to suppress target gene activity. Blocking its activity (e.g., "sponging") to relieve inhibition of target genes. These mechanisms operate through sequence-specific binding to mRNA 3’-UTRs, causing mRNA degradation or translational inhibition.