MicroRNA-377-3p (miR-377-3p)

MicroRNA-377-3p (miR-377-3p) is a small, endogenous, non-coding RNA molecule classified as a microRNA that functions primarily in the post-transcriptional regulation of gene expression by binding to complementary sequences on target messenger RNAs (mRNAs), inhibiting their expression through degradation or translational repression. miR-377-3p regulates multiple cellular processes—most notably cell proliferation, apoptosis, migration, and phenotypic transitions—by targeting mRNAs such as MMP-16 (in ovarian cancer), CPT1C (in hepatocellular carcinoma), ARMC8 (in melanoma), and NRP2 (in vascular smooth muscle cells). Decreased miR-377-3p expression has been documented in various cancers and cardiovascular conditions, supporting its role as a tumor suppressor and a potential therapeutic and prognostic biomarker[1][2][3][5]. Current efforts focus on developing miR-377-3p mimics or agomirs as therapeutic agents, though direct drugs or approved therapies targeting miR-377-3p are not yet available.

Other names

hsa-miR-377-3pmiR-377-3p

Gene silencing via binding to target mRNA 3′ untranslated regions (UTR) to inhibit translation or promote degradation, e.g., targeting MMP-16, CPT1C, ARMC8, and NRP2[1][2][3][5]