MicroRNA 378c (MIR378C)

MicroRNA 378c (MIR378C) is a short, non-coding RNA molecule that regulates gene expression by binding target mRNAs, leading to translation inhibition or mRNA destabilization via the RISC complex[2][3]. MIR378C is implicated in the regulation of cell migration, invasion, apoptosis, autophagy, cell proliferation, and angiogenesis, with multifaceted roles in cancer (as both an oncogene and tumor suppressor) and cardiovascular disease (acting as a cardioprotective regulator)[1][3]. Its expression is altered in multiple pathologies, and it is under investigation as a biomarker and potential therapeutic target. Experimental modulation is typically performed via oligonucleotide mimics or inhibitors. No drugs are clinically approved for targeting MIR378C, and its safety profile in therapeutic contexts is not well established[1][3].

Other names

hsa-mir-378cmir-378cMIR378CMicroRNA 378c

Gene silencing via RNA-induced silencing complex (RISC): miR-378c binds target mRNAs by imperfect base pairing, inhibiting translation or promoting degradation. Regulation of signaling pathways: Direct targeting of key proteins (e.g., ATG12, MAPK6, Samd1, Cyclin D1, pRb). Modulation of tumor suppressor and oncogene networks. Influence in autophagy and apoptosis through regulation of key mediators.