MicroRNA 378d-1 (MIR378D1)

MicroRNA 378d-1 (MIR378D1) is a short, non-coding RNA gene that regulates gene expression by binding to target mRNAs and inhibiting their translation or promoting their degradation. MIR378D1 is transcribed as part of a primary transcript (pri-miRNA) and processed by ribonucleases (Drosha and Dicer) into its mature form, which is incorporated into the RNA-induced silencing complex (RISC). miR-378d-1, as part of the broader miR-378 family, is implicated in key biological processes such as cell proliferation, apoptosis, differentiation, metabolic regulation (notably in adipose and cardiac tissues), and angiogenesis. It has been experimentally linked to various diseases including cancers and cardiovascular conditions, and its expression pattern is being evaluated as a non-invasive biomarker for cancer detection, progression, and prognosis. No direct drug therapies currently target MIR378D1, but experimental strategies for miRNA modulation are under investigation. This information is synthesized based on current genetic, biomedical, and functional data and reflects the current standard understanding of microRNA 378d-1 and its gene MIR378D1.

Other names

hsa-mir-378d-1mir-378d-1MIR378D1

Not applicable (standard drugs do not directly target this microRNA; experimental strategies may use anti-miRs or miRNA mimics to upregulate or downregulate its activity.)