microRNA 378j (miR-378j)

microRNA 378j (miR-378j) is a member of the microRNA-378 family, which are small, non-coding RNA molecules that regulate gene expression at the post-transcriptional level[1][3]. Each variant of miR-378, including miR-378j, is coded at a different genomic location, but shares a similar “seed” sequence, enabling them to target overlapping sets of messenger RNAs for silencing[1]. miR-378 family members, including those annotated as miR-378a/b/c/d/e/f/g/h/i/j, have been studied collectively, with much of the literature focused on the predominant or “a” isoform (miR-378a)[1].\nThe broader miR-378 family is implicated in cardiovascular diseases such as myocardial infarction, heart failure, and coronary heart disease. It plays a regulatory role in myocardial hypertrophy, fibrosis, remodeling, mitochondrial energy metabolism, and angiogenesis. Altered levels of miR-378 (including various isoforms) in blood or heart tissue correlate with disease status and prognosis[1].\nHowever, very little, if any, *isoform-specific* literature exists for “miR-378j,” and it is usually grouped with the more general miR-378 family for functional and clinical research. It is important to note that some biological databases and sources do not have separate, curated data on miR-378j; this specific isoform's individual biological role or therapeutic targeting potential is not established, while the general miR-378 family is well-documented in cardiovascular contexts[1].\n\n**Key issues:**\n- The name “microRNA 378j” is technically valid as a family member but has almost no isoform-specific functional or disease information available in the literature[1]. Most research and biomarker data refer collectively to miR-378 or the major isoforms like miR-378a[1].\n- As a microRNA, miR-378j is not a pharmacological *target* like a receptor, enzyme, or ion channel, and there are no drugs that target this specific isoform; the functional manipulation of the overall miR-378 family (e.g., via antagomirs) affects multiple isoforms simultaneously[1].\n- No safety concerns or drug mechanism data are available specifically for miR-378j.\n\n**Summary:**\nmicroRNA 378j (miR-378j) is a minor member of the microRNA-378 family, known to be involved in post-transcriptional regulation of gene expression, particularly in heart development and cardiovascular diseases, but it is *not recognized as a distinct therapeutic target* due to lack of isoform-specific data and the general focus on the whole family or major isoforms in existing studies[1][3].

Other names

hsa-mir-378jmicroRNA mir-378jMIR378J