MicroRNA 379 (MIR379)

MicroRNA 379 (MIR379) is a non-coding RNA molecule encoded by the MIR379 gene located on chromosome 14q32.31[1][3]. It is part of the large miR-379/656 cluster, one of the largest and most differentially regulated miRNA clusters in the human genome[2][5]. miR-379 is processed into a mature, ~22-nucleotide RNA that acts as a post-transcriptional regulator of gene expression, influencing the stability and translation of numerous mRNA targets[3]. It plays essential biological roles including tumor suppression, regulation of apoptosis, and modulation of metabolic and cardiovascular processes. miR-379 has been implicated in the pathogenesis of cancers (especially breast and brain cancer), diabetic kidney disease, cardiomyopathy, and neuromuscular diseases[1][2][3][5]. Its dysregulation is a diagnostic and prognostic biomarker in cancer, and it is being investigated as a potential therapeutic target through anti-miR or mimic approaches. It mediates effects through direct binding to 3'-UTR sites in key target mRNAs like Smurf1 and EDEM3, thus influencing pathways related to cell cycle, DNA repair, mitochondrial function, and cell death[1][5].

Other names

hsa-mir-379MIRN379mir-379MIR379miR-379miR-379-5p

Target for oligonucleotide inhibitors (antagomirs, anti-miRs). Potential use of mimics for miRNA replacement therapies.