MicroRNA-384 (miR-384)

MicroRNA-384 (miR-384) is a small, non-coding RNA molecule that functions principally as a post-transcriptional regulator of gene expression by binding to target mRNAs, leading to their degradation or translational inhibition[2][3]. It is widely studied for its tumor suppressor activity in several cancers, where decreased expression is often correlated with increased cell proliferation, invasion, and poor clinical prognosis[2][3]. In renal cell carcinoma and nasopharyngeal carcinoma, overexpression of miR-384 inhibits tumor growth and invasiveness by directly targeting oncogenes such as AEG-1 and Smad5 and by inactivating signaling pathways such as Wnt/β-catenin[2][3]. In the immune system, miR-384 modulates T helper 17 (Th17) cell differentiation and function, thereby impacting autoimmune disease models like experimental autoimmune encephalomyelitis[1]. Given its regulatory roles in fundamental cellular processes, miR-384 is being explored both as a therapeutic target and as a biomarker for disease diagnosis and prognosis. No known approved drugs directly target MicroRNA-384, but it is under investigation as a therapeutic target due to its tumor-suppressive and immunomodulatory functions[2][3].

Other names

hsa-miR-384MIR384MIRN384hsa-mir-384

Modulation of mRNA degradation and translational repression via sequence-specific binding to target mRNAs[2][3]