MicroRNA 3907 (miR-3907)

MicroRNA 3907 is a small non-coding RNA molecule present in humans, part of the miRNA family that regulates gene expression post-transcriptionally, typically by binding complementary sequences on target mRNAs to promote their degradation or inhibit their translation[3][4]. Its biological function has been recently linked with cancer progression: miR-3907 is found upregulated in sebaceous gland carcinoma of the eyelid and lung cancer, where it promotes cell proliferation and migration by downregulating the tumor suppressor gene thrombospondin 1 (THBS1), suggesting both diagnostic utility and therapeutic potential[1][2]. It has also been proposed as a biomarker for polycystic kidney disease due to its distinct expression profile in affected tissues[1]. As of September 2025, no drugs directly targeting miR-3907 are in clinical use, but modulation of its activity via miRNA inhibitors or mimics has shown promise in preclinical research.

Other names

microRNA-3907MIR3907hsa-mir-3907

Drugs (experimental or theoretical) targeting miR-3907 would act by: - Inhibiting miR-3907 activity to restore expression of its mRNA targets such as THBS1[1][2] - miRNA mimics or inhibitors (used experimentally to modulate its activity in cell models[1])