Target intelligence / Profile preview

MicroRNA 3913-1 (MIR3913-1)

Target
MIR3913-1
Molecular classification
MicroRNA, Non-coding RNA
01

Overview

MicroRNA 3913-1 is a short (~20-24 nucleotides), non-coding RNA molecule that belongs to the microRNA (miRNA) family, whose primary function is to regulate gene expression post-transcriptionally by binding to complementary mRNA sequences and inhibiting their translation or promoting their degradation[1]. MIR3913-1 is transcribed as part of a longer precursor RNA that is sequentially processed by Drosha and Dicer enzymes to yield the mature miRNA, which associates with the RNA-induced silencing complex (RISC) and guides it to target mRNAs via sequence complementarity[1][2]. While many microRNAs are implicated in cancer—acting either as tumor suppressors or as oncogenes (oncomirs)—the specific functional roles, target genes, and disease associations for MIR3913-1 remain to be fully elucidated, and there is no evidence that it is a direct therapeutic target or has known drug interactions at present[1][3][4]. The gene is cataloged by authoritative databases (HGNC:38884, NCBI Gene:100500903, Ensembl:ENSG00000264405, miRBase:hsa-mir-3913-1) which confirms proper nomenclature and usage[1].

Other names
hsa-mir-3913-1mir-3913-1MIR3913-1
02

Mechanism of action

Not applicable; microRNAs act via RNA-induced silencing complex (RISC) to regulate target gene expression by translational inhibition or mRNA degradation[1]

03

Biological functions

Post-transcriptional gene regulationmRNA silencingCell proliferationCell differentiationApoptosis
04

Disease associations

Potential role in cancer, but specific association with diseases, including cancer types or other pathological roles, is not yet well characterized for MIR3913-1
05

Safety considerations

None described for this individual microRNA; therapeutic targeting of microRNAs in general poses challenges such as off-target effects and systemic delivery issues[2]

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