MicroRNA 3913-2 (MIR3913-2)

MicroRNA 3913-2 (MIR3913-2) is a short, non-coding RNA molecule (about 20–24 nucleotides) encoded in the human genome and classified as a microRNA[1][4]. Like other microRNAs, it acts primarily to negatively regulate gene expression post-transcriptionally, either by inhibiting translation or promoting degradation of target mRNAs through imperfect base-pairing and incorporation into the RNA-induced silencing complex (RISC)[3]. MIR3913-2 has been specifically implicated as a tumor suppressor in colorectal cancer, functioning by downregulating oncogenic targets such as CREB5, and its transcription is itself negatively regulated by ATF2[2]. The mature product miR-3913-5p is notably decreased in colorectal cancer cells and tissues, and its restoration has been shown to inhibit cell proliferation, migration, and invasion in experimental systems[2]. Thus, it has potential utility as a target for cancer therapeutics and as a biomarker for cancer diagnosis or prognosis[2]. Fundamental knowledge about MIR3913-2 derives from comprehensive annotation databases (GeneCards, Alliance Genome Resources) and cancer biology literature[1][2][4].

Other names

hsa-mir-3913-2mir-3913-2MIR3913-2miR-3913-5p

Regulation of target mRNAs (e.g., CREB5) through binding to 3′UTR, leading to inhibition of translation and/or degradation of target transcript