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Target intelligence / Profile preview
microRNA 3917 (MIR3917)
- Target
- MIR3917
- Molecular classification
- microRNA, Non-coding RNA, Other
01
Overview
microRNA 3917 (MIR3917) is a short non-coding RNA molecule (microRNA) that regulates gene expression in multicellular organisms by post-transcriptional mechanisms, such as inhibiting the translation or destabilizing target mRNAs[1]. MIR3917 is highly expressed in certain lung cancer tissues, particularly within exosomes derived from M2 macrophages, and has been shown to promote lung cancer cell proliferation, migration, and invasion by targeting and downregulating G protein-coupled receptor kinase 6 (GRK6)[1]. This oncogenic role, particularly in non-small cell lung cancer, suggests MIR3917 is both a potential therapeutic target and a biomarker for tumor progression[1].
- Other names
- MIR-3917hsa-mir-3917mir-3917
02
Mechanism of action
Gene silencing via inhibition of target mRNA translation; mRNA destabilization
03
Biological functions
Post-transcriptional regulation of gene expressionRegulation of mRNA stabilityRegulation of mRNA translationCell proliferationCell migrationCell invasion
04
Disease associations
CancerLung cancerTumor progression
05
Safety considerations
Potential for off-target effects due to broad regulatory activity of microRNAsTumor-promoting effects if deregulated or delivered inappropriately
06
Biomarkers
Potential biomarker for non-small cell lung cancer (tissue and exosomal expression)
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