microRNA-3941 (miR-3941)

MicroRNA-3941 (miR-3941) is a small, non-coding RNA molecule that functions as a microRNA, primarily involved in the post-transcriptional regulation of gene expression. It is found to be downregulated in breast cancer cells, where it negatively regulates the expression of targets such as insulin-like growth factor 1 (IGF-1), impacting cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT). Overexpression of miR-3941 can suppress malignant properties in breast cancer cells by targeting IGF-1[1]. miR-3941 is also implicated in inflammatory processes, where it targets insulin-like growth factor 2 (IGF-2) and modulates the PI3K/AKT pathway, relevant in LPS-induced acute pneumonia. In this context, miR-3941 alleviates cell injury, influences apoptosis, and inflammatory cytokine production in lung epithelial cells[2]. These functions suggest potential utility as a biomarker or therapeutic target in cancer and inflammation, although no specific drugs directly target miR-3941 or use it for patient selection to date. Key attributes: - Not a classical protein target (e.g., receptor, enzyme), but a microRNA regulating disease-relevant genes. - No direct drug interactions or known safety concerns reported. - Functions as a regulator rather than a typical receptor or enzyme target[1][2].

Other names

hsa-mir-3941MIR3941mir-3941hsa-miR-3941