MicroRNA 410-3p (miR-410-3p)

MicroRNA 410-3p (miR-410-3p) is a mature microRNA molecule that functions as a critical post-transcriptional regulator of gene expression (NIH, 2026). It is derived from the 3' arm of the pre-miR-410 precursor, which is located within the DLK1-DIO3 imprinted cluster on chromosome 14q32.31 (NIH, 2023). miR-410-3p exerts its biological effects by binding to the 3'-untranslated regions (3'-UTRs) of target messenger RNAs, such as IRS-1, Smad7, and PTEN, leading to their degradation or translational repression (NIH, 2026; PubMed, 2021). This microRNA is involved in diverse cellular processes, including cell proliferation, apoptosis, and epithelial-mesenchymal transition (EMT) (NIH, 2024). In human disease, miR-410-3p plays a complex, context-dependent role; it acts as a tumor suppressor in gastric and breast cancers but functions as an oncogene in colorectal and lung cancers (NIH, 2024; PubMed, 2018). Additionally, it is implicated in cardiovascular pathologies like cardiac hypertrophy and serves as a potential diagnostic biomarker for neonatal hypoxic-ischemic encephalopathy (NIH, 2021). Therapeutic strategies currently focus on the use of synthetic miRNA mimics to restore its function or antagomirs to inhibit its activity in specific disease states (MedChemExpress, 2023). Challenges in targeting miR-410-3p include off-target effects due to its ability to regulate multiple genes and the need for efficient, tissue-specific delivery systems (CAS, 2025).

Other names

hsa-miR-410-3pMIR410microRNA 410miR-410

Post-transcriptional gene silencing via mRNA degradation or translational inhibition by binding to the 3'-untranslated region (3'-UTR) of target genes