MicroRNA 412 (MIR412)

MicroRNA 412 (MIR412) is a small, non-coding RNA found in humans, classified as a microRNA. It is involved in the post-transcriptional regulation of gene expression by binding to complementary sequences in target mRNAs, leading to their degradation or inhibition of translation[1]. MIR412 is produced as part of a primary transcript, processed via Drosha and Dicer enzymes, and incorporated into the RNA-induced silencing complex (RISC), which mediates its regulatory effects[1]. Recent experimental data suggest that miR-412-5p can attenuate inflammatory responses in heart muscle cells by targeting various molecules such as COX-2, iNOS, and key signaling kinases in the MAPK pathway[2]. Disease associations include hemorrhoids, alcohol use disorder, and potential involvement in cardiovascular inflammation and cancer regulation, mainly supported by preclinical molecular studies[1][2][3]. No approved drugs specifically target miR-412; research focuses on RNA delivery, exosome-mediated transfer, and gene modulation approaches[2].

Other names

hsa-mir-412MIRN412mir-412

Drugs (or exosome treatments) that increase miR-412-5p can suppress inflammatory pathways by targeting MAPK, COX-2, iNOS, and cytokine production in cardiomyocytes