MicroRNA 425 (miR-425)

MicroRNA 425 (miR-425) is a short, non-coding regulatory RNA molecule that primarily functions in the post-transcriptional regulation of gene expression by binding to target mRNAs and inhibiting their translation or promoting their degradation. It is involved in numerous physiological and pathological processes, including cell proliferation, apoptosis, migration, and differentiation. MiR-425 acts as a key regulator in cardiovascular diseases by modulating cardiac function, remodeling, and inflammation, and has been implicated in tumorigenesis across multiple cancer types by affecting tumor cell proliferation, apoptosis, migration, invasion, and chemoresistance. Its circulating levels can serve as a diagnostic and prognostic biomarker, particularly in cancer and cardiovascular conditions. Because of its central regulatory role and disease associations, miR-425 is widely researched as both a biomarker and a potential therapeutic target, though clinical translation faces challenges regarding specificity and safety.

Other names

hsa-mir-425MIR425MIRN425mir-425hsa-mir-425-5pmiR-425-5pmiR-425-3p

AntimiR oligonucleotides: Inhibit endogenous miR-425 function by complementary binding, leading to derepression of its target genes. miR-425 mimics: Restore or enhance miR-425 activity to suppress disease-promoting target genes.