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Target intelligence / Profile preview
MicroRNA 4286 (miR-4286)
- Target
- miR-4286
- Molecular classification
- Other (microRNA, small non-coding RNA)
01
Overview
MicroRNA 4286 (miR-4286) is a short, non-coding RNA molecule involved in post-transcriptional regulation of gene expression by binding to target mRNAs and inhibiting their translation or promoting their degradation. It is detectable in human serum and exhibits altered expression in certain cancers (notably squamous cell carcinoma of the lung) and in lesions of neurodegenerative disease such as multiple sclerosis[1][2][3][4]. miR-4286 may regulate cell proliferation, survival, and apoptosis, possibly via modulation of the PI3K/Akt pathway, and is under study for its potential as a blood-based biomarker for cancer diagnosis and monitoring[1][2][3]. No therapeutics specifically targeting miR-4286 are currently approved or in advanced clinical development.
- Other names
- hsa-mir-4286mir-4286MIR4286microRNA-4286
02
Mechanism of action
microRNA-mediated silencing of mRNA targets (post-transcriptional gene regulation)
03
Biological functions
Post-transcriptional gene silencingRegulation of mRNA stabilityCell proliferationCell survivalApoptosis
04
Disease associations
CancerChemoresistanceNeurodegenerative disease (Multiple sclerosis)Other
05
Safety considerations
Lack of well-established safety profile as a therapeutic targetunknown toxicity and delivery challenges common to RNA-based targeting
06
Biomarkers
Diagnostic biomarker for squamous cell carcinoma (SqCC) of the lungPotential biomarker for multiple sclerosis lesionsPossible utility in cisplatin resistance in non-small cell lung cancer (NSCLC)
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