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MicroRNA 4299 (miR-4299)
- Target
- miR-4299
- Molecular classification
- MicroRNA, Non-coding RNA, Regulatory RNA, Other (not a receptor, transporter, or enzyme)
01
Overview
MicroRNA 4299 is a small non-coding RNA, approximately 22 nucleotides in length, that regulates gene expression post-transcriptionally. It functions by binding to complementary sequences in messenger RNA (mRNA), leading to mRNA degradation or translational repression. miR-4299 acts as a tumor suppressor in non-small cell lung cancer by modulating the PTEN/AKT/PI3K signaling pathway, inhibiting cell proliferation, migration, and invasion; lower expression of miR-4299 correlates with more aggressive disease and poor prognosis[2]. MicroRNAs are implicated broadly in biological processes and diseases such as cancer, neurodegeneration, and immune regulation, making them valuable as both therapeutic targets and biomarkers[1][5].
- Other names
- hsa-mir-4299MIR4299miR-4299
02
Mechanism of action
Drugs or biologicals targeting microRNAs generally act via: miRNA inhibition (antagomirs binding and inactivating the microRNA) miRNA mimicry (synthetic miRNAs restoring lost microRNA function) Modulation of gene expression via RNA interference mechanisms
03
Biological functions
Gene silencingPost-transcriptional regulationCell proliferationCell migrationCell invasionTumor suppression
04
Disease associations
Cancer (specifically non-small cell lung cancer)Potential biomarker and therapeutic target in other diseases such as Alzheimer's disease and neurodegeneration (general microRNA class evidence)Other (due to general microRNA roles in immune response, inflammation, and differentiation)
05
Safety considerations
Off-target gene silencing (typical for microRNA therapy and inhibition)Immune activationDelivery challenges, stability, and specificity issues for RNA-based drugs
06
Biomarkers
miR-4299 expression level (as a prognostic marker in non-small cell lung cancer)General use of microRNA levels in blood or tissues as biomarkers for cancer prognosis, diagnosis, or therapeutic response
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