MicroRNA 4311 (MIR4311)

MicroRNA 4311 is a short (20–24 nucleotides) non-coding RNA molecule transcribed by RNA polymerase II as a precursor, which is processed by Drosha and Dicer into a mature miRNA, then incorporated into the RNA-induced silencing complex (RISC). MIR4311 participates in the regulation of gene expression at the post-transcriptional level, recognizing target mRNAs through sequence pairing and modulating their translation or stability. In cellular studies, MIR4311 has been implicated in regulatory networks influencing radioresistance and cancer biology, including interaction with other non-coding RNAs (e.g., LINC00472 acts as a molecular sponge for MIR4311 to modulate its function in oral squamous cell carcinoma). Although no approved drugs directly target MIR4311 specifically, its role as a biomarker and potential therapeutic target is supported by emerging evidence in cancer research.

Other names

MIR4311hsa-mir-4311

For microRNA-targeting agents: inhibition by antisense oligonucleotides, or modulation of miRNA activity using molecular sponges or mimics (general mechanism for therapeutic miRNA manipulation). MIR4311 itself functions via imperfect base pairing with target mRNAs, resulting in their translational inhibition or destabilization.