Target intelligence / Profile preview

MicroRNA 4314 (MIR4314)

Target
MIR4314
Molecular classification
MicroRNA, Non-coding RNA, Gene regulator
01

Overview

MicroRNA 4314 (MIR4314, also known as hsa-mir-4314) is a small, non-coding RNA molecule classified as a microRNA. MicroRNAs are highly conserved gene regulators that bind to complementary sequences in target messenger RNAs, typically resulting in post-transcriptional repression or degradation of the targeted mRNAs[2][3][5][8]. Each microRNA—including MIR4314—can regulate multiple genes, often participating in complex regulatory networks that control key cellular processes such as proliferation, differentiation, apoptosis, and responses to environmental cues[2][4]. While MIR4314 itself has not been robustly characterized in major experimental or clinical studies, microRNAs as a class play prominent roles in gene expression regulation and are implicated in the pathogenesis of various diseases, most notably cancer[1][2][9]. The related microRNA, miR-4510, was recently suggested to act as a tumor suppressor and potential biomarker in breast cancer by downregulating *TP53*, *TP53INP1*, *MMP11*, and *COL1A1*, and loss of its expression may promote tumorigenesis[1]. However, *direct evidence for MIR4314 in human disease remains scant*, and no direct drug interactions or use as a formal biomarker have been established. In summary, MIR4314 is a gene-regulatory microRNA belonging to the non-coding RNA family, with generic microRNA functions in regulating gene expression, but no established status as a direct therapeutic target, formal disease biomarker, or drug-interaction partner as of current scientific knowledge[1][2][3][4][5][8].

Other names
hsa-mir-4314MIR4314miR-4314
02

Mechanism of action

Not applicable

03

Biological functions

Post-transcriptional gene silencingRegulation of gene expressionPotential tumor suppressor role, particularly demonstrated in some studies for breast cancer where MIR4314 (miR-4510 in those reports, but miR-4314 appears not directly studied—see below)
04

Disease associations

CancerPotentially Other
05

Safety considerations

Delivery and specificity problems are general concerns for microRNA-based therapeutics.Off-target effects are a risk for any RNA-based modulation.Limited clinical validation of MIR4314-specific intervention
06

Interacting drugs

None known
07

Biomarkers

None confirmed

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