MicroRNA 4320 (MIR4320)

MicroRNA 4320 (MIR4320) is a small non-coding RNA (typically 20–24 nucleotides) involved in regulating gene expression after transcription, primarily by interfering with the stability and translation of messenger RNAs through interaction with the RNA-induced silencing complex (RISC)[1][2][3][6]. It is encoded by the MIR4320 gene (HGNC: 38369), and its mature form is processed by Drosha and Dicer enzymes. Like other miRNAs, MIR4320 can modulate cellular processes by silencing or activating gene expression and may circulate extracellularly as a chemical messenger[6]. MIR4320 has been linked to intracranial berry aneurysm according to gene association databases, although its broader physiological and pathological roles remain to be determined[1].

Other names

MIR4320hsa-mir-4320

Drugs targeting microRNA generally act via inhibition of microRNA function, restoration of normal gene expression, or modulation of downstream targets. Mechanisms include blocking the seed region, altering miRNA stability, or binding to miRNA-mRNA complexes[3][6][7].