MicroRNA-4421 (miR-4421)

MicroRNA-4421 (miR-4421) is a small, non-coding RNA molecule found in humans that functions as a microRNA. Like other microRNAs, miR-4421 regulates gene expression at the post-transcriptional level, primarily by binding to complementary sequences in the 3′ untranslated regions (UTRs) of target mRNAs, resulting in translational repression or mRNA degradation[5]. miR-4421 has been shown to interact with the 3′-UTR of the *ERP29* gene, and genetic variants that affect this interaction have been linked to differences in cancer risk and prognosis, particularly in oropharyngeal squamous cell carcinoma[1]. The broader biological roles of miR-4421 are likely to include common microRNA functions such as regulation of cell proliferation, differentiation, and survival[6], though specific validated targets and functions beyond *ERP29* are still under study. There are currently no approved drugs or clinical therapeutics that directly target miR-4421, but research tools such as synthetic mimics and inhibitors are used for experimental modulation of its function[1].

Other names

MIR4421hsa-mir-4421hsa-mir-4421 (multiple spellings/capitalizations in literature)

Not directly targeted by drugs; molecular tools such as synthetic mimics or inhibitors can modulate its activity in laboratory research[1] Modulates target gene *ERP29* by binding its 3′-UTR, resulting in repression of gene expression via mRNA degradation and/or translational inhibition[1][5]