MicroRNA 4433a (MIR4433A)

MicroRNA 4433a (MIR4433A) is a member of the microRNA family, a class of small (20–24 nucleotide) non-coding RNAs that post-transcriptionally regulate gene expression by binding and modulating the stability and translation of target mRNAs[2][4]. Like other miRNAs, MIR4433A is processed from a primary transcript (pri-miRNA) to a precursor and then a mature form that incorporates into the RNA-induced silencing complex (RISC), guiding the repression of specific mRNAs. MIR4433A has been identified as differentially expressed in the serum of patients with lung adenocarcinoma, where its 3p variant (miR-4433a-3p) serves as a sensitive and specific blood biomarker for early detection and therapeutic monitoring[1]. It may influence tumour growth and metastasis by targeting genes such as PIK3CD, UBE2J2, ICMT, and PRDM16, and by modulating relevant cancer-associated signalling pathways (MAPK, Ras, PI3K/AKT)[1]. There are currently no known drug interactions or approved therapeutics targeting MIR4433A. Its broader role and disease specificity require further study, as limited clinical and mechanistic information is available.

Other names

hsa-mir-4433ahsa-mir-4433MIR4433MIR4433AmicroRNA 4433