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microRNA 4433b-5p (miR-4433b-5p)
- Target
- miR-4433b-5p
- Molecular classification
- MicroRNA, Non-coding RNA, Regulatory RNA, Other
01
Overview
MicroRNA 4433b-5p (miR-4433b-5p, also known as hsa-miR-4433b-5p) is a small, non-coding single-stranded RNA molecule that belongs to the microRNA family. As a post-transcriptional regulator, it binds to complementary sequences on target messenger RNAs (mRNAs), leading to their degradation or repression of translation. It does not encode a protein, nor is it considered an enzyme, receptor, transporter, or traditional drug target. Recent studies have highlighted miR-4433b-5p as a potentially valuable biomarker for breast cancer: it is overexpressed in serum and underexpressed in tumor tissue compared to controls and may discriminate between breast cancer subtypes when used in combination with other microRNAs[1][3]. There is no evidence that miR-4433b-5p is directly targeted by marketed drugs or approved therapeutic agents, and its value lies primarily in cancer diagnostics and subtype discrimination.
- Other names
- miR-4433b-5phsa-miR-4433b-5pmicroRNA 4433bMIR4433B
02
Biological functions
Post-transcriptional gene regulationModulation of mRNA stability and translationPotential involvement in cell differentiation, proliferation, and apoptosis (as is common with microRNAs)Other
03
Disease associations
Cancer (notably breast cancer)Other (pending further evidence)
04
Biomarkers
Diagnostic biomarker in breast cancer, useful for distinguishing tumor versus non-tumor tissue, and different subtypes (e.g., luminal A vs. triple-negative breast cancer) when combined in panels with other microRNAs[1][3].Potential prognostic biomarker, especially in multiplexed microRNA panels for breast cancer[1][3].
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