microRNA 4435-1 (miR-4435-1)

microRNA 4435-1 (miR-4435-1) is a human microRNA gene that encodes a short non-coding RNA molecule involved in post-transcriptional gene regulation. It does not code for a protein, but instead mediates gene silencing by base pairing with complementary sequences within target messenger RNAs (mRNAs), leading to mRNA degradation or inhibition of translation. There is no direct evidence that miR-4435-1 itself is a therapeutic target or that inhibitors or mimics of miR-4435-1 are in clinical use. However, a related microRNA, miR-4435, has been described as an oncogenic circulating biomarker in colorectal cancer, likely functioning via regulation of tumor suppressor gene TIMP3, with a role in promoting migration and invasion of cancer cells[3]. Information specifically on “microRNA 4435-1” is sparse, and the scientific literature generally references the mature miR-4435 sequence and function, rather than the specific “-1” gene variant. This suggests a potential naming or locus-specific ambiguity (e.g. distinguishing between the precursor gene and the mature miRNA product). Thus, “microRNA 4435-1” likely denotes a genomic locus producing the miR-4435 precursor, which is then processed to the mature active miRNA; detailed disease roles, drug interactions, and mechanistic data are only available for the mature miR-4435 sequence, not specifically for the -1 locus[3]. Summary of issues: - “microRNA 4435-1” is not a canonical therapeutic target such as a receptor, enzyme, or transporter; rather, it is a gene encoding a microRNA, with biological activity attributed to the mature miR-4435 product. - There is ambiguity or insufficient distinction in the literature between “miR-4435” (mature sequence) and “miR-4435-1” (gene locus), so caution is needed interpreting results. - There are no known drugs that directly target this miRNA or its gene locus. - Most functional, diagnostic, and disease-relevant information pertains to the mature miR-4435, not specifically “miR-4435-1” or “MIR4435-1” as an individual entity. References: Major supporting data are from work showing that miR-4435 (note: not gene-specific) is associated with colorectal cancer, upregulated in patient samples, may modulate cell proliferation and invasion, and could serve as a circulating biomarker[3]. No evidence was found supporting a protein, receptor, transporter, or canonical druggable target status for "MIR4435-1"[3].

Other names

MIR4435-1hsa-mir-4435-1mir-4435-1

Targeting mRNA (sequence-specific inhibition of target gene expression through mRNA binding and subsequent degradation or translational repression)