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Target intelligence / Profile preview
MicroRNA 4453 (MIR4453)
- Target
- MIR4453
- Molecular classification
- MicroRNA, Non-coding RNA, Other
01
Overview
MicroRNA 4453 (MIR4453) is a human microRNA gene that encodes a short non-coding RNA molecule involved in the post-transcriptional regulation of gene expression. Like other microRNAs, MIR4453 is processed from a primary transcript into a mature 20–24 nucleotide RNA that is incorporated into the RNA-induced silencing complex (RISC), which targets messenger RNAs for translational inhibition or degradation through imperfect base pairing. The specific biological roles and disease associations of MIR4453 are currently not well characterized, but the general function of microRNAs includes fine-tuning protein output and buffering gene expression to promote cellular robustness.
- Other names
- hsa-mir-4453MIR4453
02
Biological functions
Post-transcriptional gene regulationmRNA destabilizationmRNA translation inhibitionFine-tuning gene expressionBuffering gene expressionOther
03
Disease associations
Evidence for microRNAs in general includes roles in cancer, cardiovascular diseases, and potentially others; however, there is no specific evidence from the search results for MicroRNA 4453 (MIR4453) in any disease
04
Safety considerations
Potential challenges with miRNA therapeutics include specificity, off-target effectsdelivery issues (general to miRNAs, not specific to MIR4453)
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