MicroRNA 4472-1 (miR-4472-1)

MicroRNA 4472-1 (miR-4472-1) is a small non-coding RNA molecule involved in the post-transcriptional regulation of gene expression. It is upregulated in highly metastatic breast cancer and correlates with larger tumor size and advanced disease stage. miR-4472-1 promotes cancer cell proliferation and metastasis primarily by directly targeting and downregulating Repulsive guidance molecule A (RGMA), a known suppressor of metastasis. This downregulation induces the epithelial-to-mesenchymal transition program by suppressing E-cadherin and initiating the expression of mesenchymal markers such as vimentin, β-catenin, and Slug[1]. miR-4472-1 is part of the broader microRNA family, which are pivotal post-transcriptional gene regulators impacting diverse biological and pathological processes, including cancer[2][3]. Its expression serves as a potential biomarker for cancer aggressiveness and therapeutic resistance in breast cancer[1].

Other names

hsa-mir-4472-1MIR4472-1miR-4472

Post-transcriptional regulation of mRNA, Direct targeting and downregulation of RGMA, Promotion of EMT markers (e.g., suppression of E-cadherin, induction of vimentin, β-catenin, and Slug)