MicroRNA 4487 (miR-4487)

MicroRNA 4487 is a non-coding RNA molecule belonging to the microRNA family, specifically expressed in humans as hsa-miR-4487. Like other microRNAs, it acts as a post-transcriptional regulator of gene expression by binding to complementary sequences in target messenger RNAs (mRNAs), leading to mRNA degradation or inhibition of translation[1][6]. Recent studies suggest that miR-4487 modulates vascular smooth muscle cell proliferation, migration, and apoptosis by targeting RAS p21 protein activator 1, implicating it in vascular disease processes[4]. In neuronal models, increased expression of miR-4487 has been associated with decreased amyloid-beta (Aβ)-induced apoptosis, suggesting a potential neuroprotective function and possible relevance in neurodegenerative diseases such as Alzheimer's disease[3]. The detailed spectrum of its mRNA targets and disease associations is still under investigation, and there are no approved drugs or broad clinical diagnostics specifically targeting this miRNA at present.

Other names

hsa-mir-4487mir-4487hsa-miR-4487MIR4487

For miRNA-targeted therapies in general: - Oligonucleotide inhibitors (anti-miRs) bind to the mature microRNA, preventing it from downregulating its mRNA targets. - Mimics or agomirs (synthetic miRNAs) may restore lost miRNA activity. No specific mechanism or therapeutics uniquely established for miR-4487 as a direct intervention.