microRNA 4496 (miR-4496)

MicroRNA 4496 (miR-4496) is a small, non-coding RNA molecule in the human genome classified as a microRNA. Like other microRNAs, miR-4496 is involved in post-transcriptional regulation of gene expression by binding to partially complementary sites, typically in the 3’ untranslated regions (3’ UTRs) of target mRNAs, leading to inhibition of translation or mRNA degradation[1][4]. In the context of disease, miR-4496 has been shown to suppress cancer-initiating properties, tumorigenesis, and chemoresistance in gastric cancer cells—particularly by downregulating β-catenin and ABCG2 in response to Helicobacter pylori infection[2]. Emerging research suggests that miR-4496, in combination with chemotherapy agents such as 5-fluorouracil, may hold therapeutic potential for targeting cancer stem-like properties and overcoming resistance to treatment[2]. As with other microRNAs, circulating levels of miR-4496 could serve as disease biomarkers, though further clinical validation is needed[1].

Other names

hsa-mir-4496hsa-miR-4496MIR4496

miR-4496-based therapies act by downregulating expression of β-catenin and ABCG2, thereby suppressing cancer cell stemness and chemoresistance[2].