microRNA-449c (miR-449c)

microRNA-449c is a member of the microRNA-449 family, a group of small non-coding RNAs involved in the post-transcriptional regulation of gene expression by binding to the 3' untranslated regions of target mRNAs, thereby influencing their stability and translation[1][5]. The miR-449 family comprises miR-449a, miR-449b, and miR-449c, and shares conserved seed sequences with the miR-34 family, forming a superfamily with overlapping functions[1][5]. These microRNAs are crucial regulators of ciliated cell differentiation, cell cycle exit, apoptosis, and mitotic spindle orientation in multiple tissues, including brain, testis, and epithelial tissues[2][5][6]. miR-449c, specifically its -5p form, has been shown to inhibit breast cancer cell proliferation, migration, and invasion by targeting ERBB2 through the JAK/STAT pathway, supporting its role as a tumor suppressor and diagnostic biomarker[3][4]. Dysregulation of miR-449c and its family members is linked with male infertility and several cancers, and their expression levels can serve as sensitive biomarkers in these conditions[2][3]. The molecular mechanisms mediated by miR-449c involve the suppression of Notch and BMP signaling pathways as well as the regulation of key cell cycle and ciliogenesis genes[2].

Other names

MIR449Chsa-mir-449cmir-449cmiRNA-449cmiR-449c-5p

Post-transcriptional gene silencing (binds 3' UTRs of target mRNAs to control stability and translation)\nRegulates drug response via modulation of fatty acid metabolism (e.g., targeting ACSL4 affecting drug extrusion pump ABCG2)[3]