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Target intelligence / Profile preview
MicroRNA 4510 (miR-4510)
- Target
- miR-4510
- Molecular classification
- MicroRNA, small non-coding RNA, regulatory RNA
01
Overview
MicroRNA 4510 (miR-4510) is a 22-nucleotide mature non-coding regulatory RNA located on chromosome 15 (35,926,856-35,926,923 bp), abundantly expressed in normal tissues but significantly downregulated in breast cancer. It acts as a tumor suppressor by negatively regulating multiple oncogenic genes, including TP53, TP53INP1, MMP11, and COL1A1. Its reduced expression is associated with increased cell growth, proliferation, invasion, and poor prognosis in breast cancer patients. MiR-4510 may serve as a biomarker for breast cancer diagnosis and prognosis, although additional evidence is needed to confirm its clinical utility[1][3][4].
- Other names
- hsa-mir-4510mir-4510MIR4510
02
Mechanism of action
No drugs currently target miR-4510 directly; its mechanism involves regulation of mRNA stability and translation through binding to mRNA 3′ UTRs[3][4][5].
03
Biological functions
Regulation of gene expressionCell growthCell proliferationCell migrationCell invasionApoptosisInflammationStress response
04
Disease associations
Cancer (Notably downregulated in breast cancer, functions as a tumor suppressor, potential biomarker for breast cancer prognosis[1])Other (Potential implication in other diseases via gene regulation, but most studied in breast cancer[1])
05
Safety considerations
Therapeutic targeting of microRNAs poses challenges such as delivery efficiency, off-target effects, and immune activation, but specific safety concerns for miR-4510 are not established in the literature[3][6].
06
Biomarkers
miR-4510 expression level (Significantly downregulated in breast cancer tissue compared to normal tissue; correlated with patient prognosis[1].)
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