MicroRNA-452-5p (miR-452-5p)

MicroRNA-452-5p (miR-452-5p) is a short, single-stranded, non-coding RNA molecule (microRNA) involved in the post-transcriptional regulation of gene expression in multicellular organisms. It regulates target gene expression by binding to complementary sequences in the 3’ untranslated region (UTR) of mRNAs, typically leading to mRNA degradation or inhibited translation. miR-452-5p is implicated in various cancers, including colorectal, liver, breast, and lung cancers, where it can act as either a tumor suppressor or promoter depending on the context. It alters key cellular processes such as proliferation, apoptosis, cell cycle progression, migration, and invasion. In colorectal and liver cancers, miR-452-5p is associated with disease progression and may serve as a biomarker or future therapeutic target[1][2][4][5][7][8]. In colorectal cancer, miR-452-5p is overexpressed in early stages, where it promotes cell proliferation (via activation of the extracellular signal-regulated kinase pathway) and inhibits EMT and invasion (through suppression of the transcription factor Slug and upregulation of E-cadherin)[1]. In hepatocellular carcinoma, miR-452-5p targets genes such as CDKN1B, contributing to oncogenic behavior[4]. It is differentially expressed in multiple cancer types and is under investigation for its diagnostic and prognostic value[5][7]. No direct small molecule or biological drugs are known to specifically target microRNA-452-5p at this time.

Other names

miR-452-5pMIR452hsa-miR-452-5p

Not directly targeted by drugs yet; functions through binding to the 3' untranslated region of mRNAs to induce degradation or inhibit translation of target genes[3][5].